Immunogen | SyntheticpeptidecorrespondingtoaminoacidssurroundingthephosphoSer603ofratSynapsinI.Theimmunogensequenceisidenticalinhuman,mouseandXenopus. |
Epitope | phosphoSer603 |
Host | Rabbit |
Specificity | SynapsinI,phosphoSer603.ThisisthesitephosphorylatedbyCalciumcalmodulinkinaseII.Theantibodyrecognizesthe~78kDSynapsinI,phosphoSer603protein.Immunolabelingisblockedbytheimmunogenpeptidebutnobythecorrespondingnon-phosphopeptide. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneisamemberofthesynapsingenefamily.Synapsinsencodeneuronalphosphoproteinswhichassociatewiththecytoplasmicsurfaceofsynapticvesicles.Familymembersarecharacterizedbycommonproteindomains,andtheyareimplicatedinsynaptogenesisandthemodulationofneurotransmitterrelease,suggestingapotentialroleinseveralneuropsychiatricdiseases.Thismemberofthesynapsinfamilyplaysaroleinregulationofaxonogenesisandsynaptogenesis.Theproteinencodedservesasasubstrateforseveraldifferentproteinkinasesandphosphorylationmayfunctionintheregulationofthisproteininthenerveterminal.MutationsinthisgenemaybeassociatedwithX-linkeddisorderswithprimaryneuronaldegenerationsuchasRettsyndrome.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenidentified. |
GeneSymbol | - SYN1
- SYN1a
- Synapsin-1
- SYNI
- SYN1b
|
Modifications | |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P17600#Neuronalphosphoproteinthatcoatssynapticvesicles,bindstotheCytoskeleton,andisbelievedtofunctionintheregulationofneurotransmitterrelease.ThecomplexformedwithNOS1andCAPONproteinsisnecessaryforspecificnitric-oxidfunctionsatapresynapticlevel. SIZE:705aminoacids;74111Da SUBUNIT:Homodimer.InteractswithCAPON.FormsaternarycomplexwithNOS1(Bysimilarity). SUBCELLULARLOCATION:Celljunction,synapse. PTM:Substrateofatleastfourdifferentproteinkinases.Itisprobablethatphosphorylationplaysaroleintheregulationofsynapsin-1inthenerveterminal.PhosphorylateduponDNAdamage,probablybyATMorATR. DISEASE:SwissProt:P17600#DefectsinSYN1areacauseofX-linkedrecessiveepilepsyassociatedwithvariablelearningdisABIlitiesandbehaviordisorders[MIM:300491]. SIMILARITY:SwissProt:P17600##Belongstothesynapsinfamily. |