UniProtSummary | FUNCTION:SwissProt:P07197#Neurofilamentsusuallycontainthreeintermediatefilamentproteins:L,M,andHwhichareinvolvedinthemaintenanceofneuronalcaliber. SIZE:916aminoacids;102448Da PTM:ThereareanumberofrepeatsofthetripeptideK-S-P,NFMisphosphorylatedonanumberoftheserinesinthismotif.ItisthoughtthatphosphorylationofNFMresultsintheformationofinterfilamentcrossbridgesthatareimportantinthemaintenanceofaxonalcaliber.&Phosphorylationseemstoplayamajorroleinthefunctioningofthelargerneurofilamentpolypeptides(NF-MandNF-H),thelevelsofphosphorylationbeingaltereddevelopmentallyandcoincidentwithachangeintheneurofilamentfunction. SIMILARITY:SwissProt:P07197##Belongstotheintermediatefilamentfamily. |