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Millipore/AB5038 | Anti-Synuclein α Antibody/AB5038/50 µL
  • Millipore/AB5038 | Anti-Synuclein α Antibody/AB5038/50 µL

Millipore/AB5038 | Anti-Synuclein α Antibody/AB5038/50 µL

价格: ¥4440.00 市场价: 7400.00
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货号: AB5038
品牌: Millipore
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    • Description
      CatalogueNumberAB5038
      Replaces04-1053
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-SynucleinαAntibody
      AlternateNames
      • alpha-synuclein
      • Alpha-synuclein
      BackgroundInformationalpha-Synucleinisasmall(140aminoacid)cytoplasmicproteinofunclearfunctionthatisenrichedinpresynapticterminalsandistheprecursorproteinofanonamyloidbetacomponentofsenileplaquesinAlzeheimer"sDisease(AD).α-Synucleinislocatedpredominantlyinthepresynapticnerveterminalsinthebrainbutisalsofoundinlowconcentrationsinalltissuesexceptliver.Recentstudieshaveshownthatabnormalaggregationandaccumulationofsynapticproteins,includingα-SynucleinmightbeassociatedwithplaqueformationinADandseemstobeamajorcomponentofLewybodiesindementiawithLewybodies(DLB).IthasalsobeenidentifiedintheGlialCytoplasmicInclusions(GCIs)foundinMultipleSystemAtrophy(MSA).
      ProductInformation
      FormatSerum
      Control
      • Humanbrainsections.
      PresentationRabbitpolyclonalserumlyophilized,nopreservatives.Reconstitutewith50μLofsteriledistilledwater.Centrifugetoremoveanyresidue.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20ºCfromdateofreceipt.
      Applications
      ApplicationAnti-SynucleinAntibody,αdetectslevelofSynuclein&hasbeenpublished&validatedforuseinIC,IH,IH(P)&WB.
      KeyApplications
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunohistochemistry(Paraffin)
      • WesternBlotting
      ApplicationNotesImmunohistochemistry:
      1:1,000-1:2,000dilutoinofapreviouslotwasusedonparaffinsections;1:4,000-1:12,000dilutionofapreviouslotwasusedonfrozensections.

      Westernblot:
      1:1,000-1:2,000.Showsa14-19kDaband.

      Immunocytochemistry:
      PreviouslotusedIC.

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenHumanalpha-synucleinresidue111-131coupledtoKLH.
      Epitopea.a.111-131
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityAlpha-synuclein.Theimmunizingpeptidewaschosentoreducecross-reactivityofAB5038withβ-synucleintoaminimum.ImmunohistochemicalandWesternblotanalysisofhumanbrainindicatesahighlevelofspecificity.
      SpeciesReactivity
      • Human
      • Rat
      SpeciesReactivityNoteHumanandrat.Hasnotbeentestedonotherspecies.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryAlpha-synucleinisamemberofthesynucleinfamily,whichalsoincludesbeta-andgamma-synuclein.Synucleinsareabundantlyexpressedinthebrainandalpha-andbeta-synucleininhibitphospholipaseD2selectively.SNCAmayservetointegratepresynapticsignalingandmembranetrafficking.DefectsinSNCAhavebeenimplicatedinthepathogenesisofParkinsondisease.SNCApeptidesareamajorcomponentofamyloidplaquesinthebrainsofpatientswithAlzheimer"sdisease.TwoalternativelysplicedtranscriptsofSNCAhavebeenidentified.Additionalsplicingmaybepresentbutthefull-lengthnatureofthesevariantshasnotbeendetermined.
      GeneSymbol
      • SNCA
      • PD1
      • NACP
      • PARK4
      • MGC110988
      • PARK1
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P37840#Maybeinvolvedintheregulationofdopaminereleaseandtransport.Solubleprotein,normallylocalizedprimarilyatthepresynapticregionofaxons,whichcanformfilamentousaggregatesthatarethemajornonamyloidcomponentofintracellularinclusionsinseveralneurodegenerativediseases(synucleinopathies).Inducesfibrillizationofmicrotubule-associatedproteintau.Reducesneuronalresponsivenesstovariousapoptoticstimuli,leADIngtoadecreasedcaspase3activation.
      SIZE:140aminoacids;14460Da
      SUBUNIT:Solublemonomerwhichcanformfilamentousaggregates.InteractswithUCHL1(Bysimilarity).InteractswithphospholipaseDandhistones.
      SUBCELLULARLOCATION:Cytoplasm.Membrane.Nucleus.Note=Membrane-boundindopaminergicneurons.Alsofoundinthenucleus.
      TISSUESPECIFICITY:Expressedprincipallyinbrainbutisalsoexpressedinlowconcentrationsinalltissuesexaminedexceptinliver.Concentratedinpresynapticnerveterminals.
      DOMAIN:SwissProt:P37840TheNACdomainisinvolvedinthefibrilformation.Themiddleregionformsthecoreofthefilaments.TheC-terminusmayregulateaggregationanddeterminethediameterofthefilaments.
      PTM:Phosphorylated,predominantlyonserineresidues.PhosphorylationbyCK1appearstooccuronresiduesdistinctfromtheresiduephosphorylatedbyotherkinases.PhosphorylationofSer-129isselectiveandextensiveinsynucleinopathylesions.Invitro,phosphorylationatSer-129promotedinsolublefibrilformation.PhosphorylatedonTyr-125byaPTK2B-dependentpathwayuponosmoticstress.&Hallmarklesionsofneurodegenerativesynucleinopathiescontainalpha-synucleinthatismodifiedbynitrationoftyrosineresiduesandpossIBLybydityrosinecross-linkingtogeneratedstableoligomers.&Ubiquitinated.Thepredominantconjugateisthediubiquitinatedform(Bysimilarity).
      DISEASE:SwissProt:P37840#DefectsinSNCAareacauseofautosomaldominantParkinsondisease1(PARK1)[MIM:168601,168600].Parkinsondisease(PD)isacomplex,multifactorialdisorderthattypicallymanifestsaftertheageof50years,althoughearly-onsetcases(before50years)areknown.PDgenerallyarisesasasporadicconditionbutisoccasionallyinheritedasasimplemendeliantrait.AlthoughsporadicandfamilialPDareverysimilar,inheritedformsofthediseaseusuallybeginatearlieragesandareassociatedwithatypicalclinicalfeatures.PDischaracterizedbybradykinesia,restingtremor,muscularrigidityandposturalinstABIlity,aswellasbyaclinicallysignificantresponsetotreatmentwithlevodopa.ThepathologyinvolvesthelossofdopaminergicneuronsinthesubstantianigraandthepresenceofLewybodies(intraneuronalaccumulationsofaggregatedproteins),insurvivingneuronsinvariousareasofthebrain.&DefectsinSNCAarethecauseofParkinsondisease4(PARK4)[MIM:605543,168600].&DefectsinSNCAarethecauseofLewybodydementia(DLB)[MIM:127750].DLBisaneurodegenerativedisorderclinicallycharacterizedbydementiaandparkinsonism,oftenwithfluctuatingcognitivefunction,visualhallucinations,falls,syncopalepisodes,andsensitivitytoneurolepticmedication.PresenceofLewybodiesaretheonlyessentialpathologicfeatures.&DepositionoffibrillaramyloidproteinsintraneuronallyasneurofibrillarytanglesischaracteristicofAlzheimerdisease(AD).SNCAisaminorproteinfoundwithinthesedeposits,butamajornonamyloidcomponent.&Brainironaccumulationtype1(NBIA1,alsocalledHallervorden-Spatzsyndrome),arareneuroaxonaldystrophy,ishistologicallycharacterizedbyaxonalspheroids,irondeposition,Lewybody(LB)-likeintraneuronalinclusions,glialinclusionsandneurofibrillarytangles.SNCAisfoundinLB-likeinclusions,glialinclusionsandspheroids.
      SIMILARITY:Belongstothesynucleinfamily.
      MolecularWeight~14-19kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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