Immunogen | GSTfusionproteinwithresidues249-323ofratAquaporin4(SwissProtaccessionnumberP47863).Itisexpectedthattheantibodymayalsoreactwithmouse(73/75),bovine(71/75),human(69/75)andrabbit(64/75)duetosequencehomology. |
Epitope | C-terminus |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Rabbit |
Specificity | Recognizesaquaporin4.Onwesternblotsofratbrainmembranes,theantibodydetectsabandmigratingatapproximately38kDacorrespondingtoaquaporin4. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneencodesamemberoftheaquaporinfamilyofintrinsicmembraneproteinsthatfunctionaswater-selectivechannelsintheplasmamembranesofmanycells.Theencodedproteinisthepredominantaquaporinfoundinbrain.Twoalternativelysplicedtranscriptvariantsencodingdistinctisoformshavebeenfoundforthisgene. |
GeneSymbol | - AQP4
- MIWC
- WCH4
- AQP-4
- aquaporin-4
- HMIWC2
- Aquaporin-4
- MGC22454
|
PurificationMethod | ImmunoAffinityPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P55087#Formsawater-specificchannel.Osmoreceptorwhichregulatesbodywaterbalanceandmediateswaterflowwithinthecentralnervoussystem. SIZE:323aminoacids;34830Da SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. TISSUESPECIFICITY:Brain-muscle>heart,kidney,lung,andtrachea. DOMAIN:SwissProt:P55087Aquaporinscontaintwotandemrepeatseachcontainingthreemembrane-spanningdomainsandapore-formingloopwiththesignaturemotifAsn-Pro-Ala(NPA). SIMILARITY:BelongstotheMIP/aquaporin(TC1.A.8)family. |
MolecularWeight | 38kDa |