Immunogen | PhosphorylatedVE-cadherin(Tyr658)syntheticpeptidecorrespondingtohumanaminoacidresiduesaroundtyrosine658.Thesequenceisconservedinmouse,rat,porcine,bovine,canine,chickenandchimpanzee. |
Host | Rabbit |
Specificity | Theantibodydetectsa120kDaproteinofVE-cadherin. |
SpeciesReactivity | |
SpeciesReactivityNote | Thissequenceis100%homologousinmouse,rat,chicken,chimpanzee,cow,dogandpigVE-cadherin. |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Thisgeneisaclassicalcadherinfromthecadherinsuperfamilyandislocatedinasix-cadherinclusterinaregiononthelongarmofchromosome16thatisinvolvedinlossofheterozygosityeventsinbreastandprostatecancer.Theencodedproteinisacalcium-dependentcell-celladhesionglycoproteincomprisedoffiveextracellularcadherinrepeats,atransmembraneregionandahighlyconservedcytoplasmictail.FunctioningasaclassiccadherinbyimpartingtocellstheABIlitytoadhereinahomophilicmanner,theproteinmayplayanimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Analternativesplicevarianthasbeendescribedbutitsfulllengthsequencehasnotbeendetermined. |
GeneSymbol | |
Modifications | |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P33151#Cadherinsarecalciumdependentcelladhesionproteins.Theypreferentiallyinteractwiththemselvesinahomophilicmannerinconnectingcells;cadherinsmaythuscontributetothesortingofheterogeneouscelltypes.Thiscadherinmayplayaimportantroleinendothelialcellbiologythroughcontrolofthecohesionandorganizationoftheintercellularjunctions.Itassociateswithalpha-cateninformingalinktothecytoskeleton. SIZE:784aminoacids;87516Da SUBCELLULARLOCATION:Celljunction.Cellmembrane;Single-passtypeImembraneprotein(Probable).Note=Foundatcell-cellboundariesandprobablyatcell-matrixboundaries. TISSUESPECIFICITY:Endothelialtissuesandbrain. SIMILARITY:SwissProt:P33151##Contains5cadherindomains. |