UniProtSummary | FUNCTION:SwissProt:Q7L0J3#Playsaroleinthecontrolofregulatedsecretioninneuralandendocrinecells,enhancingselectivelylow-frequencyneurotransmission.PositivelyregulatesvesiclefusionbymaintainingthereADIlyreleasablepoolofsecretoryvesicles(Bysimilarity). SIZE:742aminoacids;82695Da SUBUNIT:InteractswithSYT1/synaptotagmin-1inacalcium-dependentmanner.BindstheadapterproteincomplexAP-2(Bysimilarity). SUBCELLULARLOCATION:Cytoplasmicvesicle,secretoryvesicle,synapticvesiclemembrane;Multi-passmembraneprotein(Bysimilarity).Note=Enrichedinchromaffingranules,notpresentinadrenalmicrosomes.Associatedwithbothinsulingranulesandsynaptic-likemicrovesiclesininsulin-secretingcellsofthepancreas(Bysimilarity). PTM:PhosphorylationbyCK1oftheN-terminalcytoplasmicdomainregulatesinteractionwithSYT1(Bysimilarity).&N-glycosylated(Bysimilarity). SIMILARITY:SwissProt:Q7L0J3##Belongstothemajorfacilitatorsuperfamily. MISCELLANEOUS:Identifiedasthebrainbinding-sitefortheantiepilepticdruglevetiracetam/lev. |