UniProtSummary | FUNCTION:SwissProt:P43005#TransportsL-glutamateandalsoL-andD-aspartate.Essentialforterminatingthepostsynapticactionofglutamatebyrapidlyremovingreleasedglutamatefromthesynapticcleft.Actsasasymportbycotransportingsodium.NegativelyregulatedbyARL6IP5(Bysimilarity). SIZE:524aminoacids;57100Da SUBUNIT:InteractswithARL6IP5/PRAF3(Bysimilarity). SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. TISSUESPECIFICITY:Expressedinalltissuestestedincludingliver,muscle,testis,ovary,retinoblastomacellline,neuronsandbrain(inwhichtherewasdenseexpressioninsubstantianigra,rednucleus,hippocampusandincerebralcorticallayers). PTM:Glycosylated. DISEASE:SwissProt:P43005#DefectsinSLC1A1maybeacauseofdicarboxylicaminoaciduria[MIM:222730];alsoknownasglutamate-aspartatetransportdefect.Thisisasdefectinrenalandprobablyintestinaltransportofglutamicandasparticacidsandisassociatedwithmoderatehyperprolinemia. SIMILARITY:SwissProt:P43005##Belongstothesodium:dicarboxylate(SDF)symporter(TC2.A.23)family. |