UniProtSummary | FUNCTION:SwissProt:Q02410#PutativefunctioninsynapticvesicleexocytosisbybindingtoMunc18-1,anessentialcomponentofthesynapticvesicleexocytoticmachinery.Maymodulateprocessingofthebeta-amyloidprecursorprotein(APP)andhenceformationofbeta-APP. SIZE:837aminoacids;92865Da SUBUNIT:PartofamultimericcomplexcontainingMunc18-1andsyntaxin-1.Alsopartofthebrain-specificheterotrimericcomplexLIN-10/X11-alpha,LIN-2/CASK,andLIN7.Bindstothecytoplasmicdomainofamyloidprotein(APP). TISSUESPECIFICITY:Brainandspinalcord. DOMAIN:SwissProt:Q02410ComposedofanN-terminaldomainthatbindsMunc18-1andLIN-2/CASK,amiddlephosphotyrosine-bindingdomain(PID/PTB)thatmediatesbindingwiththecytoplasmicdomainofthebeta-amyloidprecursorprotein,andtwoC-terminalPDZdomainsthoughttoattachproteinstotheplasmamembrane. SIMILARITY:Contains2PDZ(DHR)domains.&Contains1PIDdomain. |