Immunogen | Syntheticpeptide. |
Host | Rabbit |
Specificity | EphrinReceptorB2.ByWesternblottheantibodyrecognizesadoubletbandat~90-118kDainadultratbrainlysate. |
SpeciesReactivity | |
AntibodyType | PolyclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | Ephrinreceptorsandtheirligands,theephrins,mediatenumerousdevelopmentalprocesses,particularlyinthenervoussystem.Basedontheirstructuresandsequencerelationships,ephrinsaredividedintotheephrin-A(EFNA)class,whichareanchoredtothemembranebyaglycosylphosphatidylinositollinkage,andtheephrin-B(EFNB)class,whicharetransmembraneproteins.TheEphfamilyofreceptorsaredividedinto2groupsbasedonthesimilarityoftheirextracellulardomainsequencesandtheiraffinitiesforbindingephrin-Aandephrin-Bligands.Ephrinreceptorsmakeupthelargestsubgroupofthereceptortyrosinekinase(RTK)family.Theproteinencodedbythisgeneisareceptorforephrin-Bfamilymembers. |
GeneSymbol | - EPHB2
- EphB2
- CAPB
- EPHT3
- Hek5
- DRT
- EPTH3
- TYRO5
- ERK
- HEK5
- MGC87492
- PCBC
- Tyro5
|
PurificationMethod | ImmunoAffinityPurified |
UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P29323#Receptorformembersoftheephrin-Bfamily.Actsasatumorsuppressor. SIZE:1055aminoacids;117493Da SUBUNIT:Theligand-activatedforminteractswithmultipleproteins,includingGTPase-activatingprotein(RASGAP)throughitsSH2domain.BindsRASGAPthroughthejuxtamembranetyrosinesresidues.InteractswithPRKCABPandGRIP1(Bysimilarity). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Brain,heart,lung,kidney,placenta,pancreas,liverandskeletalmuscle.Preferentiallyexpressedinfetalbrain. DISEASE:SwissProt:P29323#DefectsinEPHB2areinvolvedintheprogressionofprostatecancer[MIM:176807].&DefectsinEPHB2areinvolvedinthedevelopmentofprostatecancermetastasistothebrain[MIM:603688]. SIMILARITY:SwissProt:P29323##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Ephrinreceptorsubfamily.&Contains2fibronectintype-IIIdomains.&Contains1proteinkinasedomain.&Contains1SAM(sterilealphamotif)domain. |
MolecularWeight | ~90-118kDa |