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Millipore/AB10020 | Anti-acetyl-Histone H2A.X (Lys5) Antibody/AB10020/100 µg
  • Millipore/AB10020 | Anti-acetyl-Histone H2A.X (Lys5) Antibody/AB10020/100 µg

Millipore/AB10020 | Anti-acetyl-Histone H2A.X (Lys5) Antibody/AB10020/100 µg

价格: ¥5676.00 市场价: 9460.00
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货号: AB10020
品牌: Millipore
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    • Description
      CatalogueNumberAB10020
      DescriptionAnti-acetyl-HistoneH2A.X(Lys5)Antibody
      AlternateNames
      • H2AXK5Ac
      • HistoneH2AX(acetylK5)
      • H2Ahistonefamily,memberX
      • H2AXhistone
      BackgroundInformationH2A.XisinvolvedinDNArepairandthemaintenanceofgenomicstABIlity,althoughitspreciseroleisstilltobedefined.H2AXisphosphorylatedsoonaftertheappearanceofdouble-strandedbreaksandhasbeenimplicatedbothinhomologousrecombinationandnonhomologousendjoiningDNArepairpathways.H2AXisthoughttohaveacriticalfunctionintherecruitmentofDNArepairfactorsandDNAdamage-signalingproteins.HyperphoshorylationofH2AXmaybelinkedtochromatinfragmentationpriortoapoptosis.
      ProductInformation
      FormatAffinityPurified
      Control
      • SodiumbutyrateuntreatedandtreatedHeLaacidextract
      PresentationPurifiedrabbitpolyclonalcontainingPBSwith0.10%ofsodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.
      Applications
      ApplicationAnti-acetyl-HistoneH2A.X(Lys5)AntibodyisaRabbitPolyclonalAntibodyfordetectionofacetyl-HistoneH2A.X(Lys5)alsoknownasH2AXK5Ac,HistoneH2AX(AcK5)&hasbeenvalidatedinWB&Mplex.
      KeyApplications
      • WesternBlotting
      • Multiplexing
      ApplicationNotesLuminex®Assay
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedlinearpeptidecorrespondingtohumanHistoneH2A.XacetylatedatLys5.
      EpitopeLys5
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificityThisantibodyrecognizesHistoneH2A.XacetylatedatLys5.
      SpeciesReactivity
      • Human
      SpeciesReactivityNoteDemonstratedtoreactwithhuman.Predictedtoreactwithrat,mouse,zebrafish,bovineandcaninebasedon100%sequencehomology.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryHistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneencodesamemberofthehistoneH2Afamily,andgeneratestwotranscriptsthroughtheuseoftheconservedstem-loopterminationmotif,andthepolyAadditionmotif.
      GeneSymbol
      • H2AFX
      • H2A.X
      • H2A/X
      • H2AX
      • H2a/x
      Modifications
      • Acetylation
      PurificationMethodAffinityPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:VarianthistoneH2AwhichreplacesconventionalH2Ainasubsetofnucleosomes.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.Requiredforcheckpoint-mediatedarrestofcellcycleprogressioninresponsetolowdosesofionizingrADIationandforefficientrepairofDNAdoublestrandbreaks(DSBs)specificallywhenmodifiedbyC-terminalphosphorylation.

      SIZE:143aminoacids;15145Da

      SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.InteractswithnumerousproteinsrequiredforDNAdamagesignalingandrepairwhenphosphorylatedonSer-140.TheseincludeMDC1,TP53BP1,BRCA1andtheMRNcomplex,composedofMRE11A,RAD50,andNBN.InteractionwiththeMRNcomplexismediatedatleastinpartbyNBN.AlsointeractswithDHX9/NDHIIwhenphosphorylatedonSer-140.

      SUBCELLULARLOCATION:Nucleus.DEVELOPMENTALSTAGE:SynthesizedinG1aswellasinS-phase.

      DOMAIN:The[ST]-QmotifconstitutesarecognitionsequenceforkinasesfromthePI3/PI4-kinasefamily.

      PTM:PhosphorylatedonSer-140(toformgamma-H2AFX)inresponsetoDNAdoublestrandbreaks(DSBs)generatedbyexogenousgenotoxicagentsandbystalledreplicationforks,andmayalsooccurduringmeioticrecombinationeventsandimmunoglobulinclassswitchinginlymphocytes.PhosphorylationcanextenduptoseveralthousandnucleosomesfromtheactualsiteoftheDSBandmaymarkthesurroundingchromatinforrecruitmentofproteinsrequiredforDNAdamagesignalingandrepair.Widespreadphosphorylationmayalsoservetoamplifythedamagesignaloraidrepairofpersistentlesions.PhosphorylationofSer-140inresponsetoionizingradiationismediatedbybothATMandPRKDCwhiledefectsinDNAreplicationinduceSer-140phosphorylationsubsequenttoactivationofATRandPRKDC.DephosphorylationofSer-140byPP2AisrequiredforDNADSBrepair.Inmeiosis,Ser-140phosphorylationmayoccuratsynaptonemalcomplexesduringleptoteneasanATM-dependentresponsetotheformationofprogrammedDSBsbySPO11.Ser-140phosphorylationmaysubsequentlyoccursatunsynapsedregionsofbothautosomesandtheXYbivalentduringzygotene,downstreamofATRandBRCA1activation.Ser-140phosphorylationmayalsoberequiredfortranscriptionalrepressionofunsynapsedchromatinandmeioticsexchromosomeinactivation(MSCI),wherebytheXandYchromosomescondenseinpachytenetoformtheheterochromaticXY-body.Duringimmunoglobulinclassswitchrecombinationinlymphocytes,Ser-140phosphorylationmayoccuratsitesofDNA-recombinationsubsequenttoactivationoftheactivation-inducedcytidinedeaminaseAICDA.&MonoubiquitinationofLys-120byRING1andRNF2/RING2complexgivesaspecifictagforepigenetictranscriptionalrepression(Bysimilarity).

      SIMILARITY:BelongstothehistoneH2Afamily.
      MolecularWeight~15kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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