Ascomycin, also known as FK520, is a macrolide immunosuppressant produced by the bacterium Streptomyces hygroscopicus var. ascomyceticus. It is an ethyl analogue of FK506 and is used for post-transplant organ rejection, autoimmune disorders and neurodegeneration.
Ascomycin inhibits T-cell activation and development by binding to calcineurin. Calcineurin is a phosphatase that dephosphorylates nuclear factors of activated T-cells. Calcineurin inhibition prevents production of interleukin 2 (IL2), interleukin 4 (IL4), and the release of cytokines.
Product SpecificationsAscomycinImmunomycinFK520
Formula: C43H69NO12
MW: 792.00 g/mol
Storage/Handling: Store desiccated at -20°C.Soluble in methanol.
PubChem Chemical ID: 5282071
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