Ampicillin/sulbactam (2:1) is a broad-spectrum combination of a β-lactam antibiotic with a β-lactamase inhibitor. It is used for in vitro susceptibility tests in microbiology, pharmacokinetics and pharmacodynamics studies.
Ampicillin binds to the active site of penicillin binding proteins (PBP), preventing peptidoglycan cross-link formation of the bacterial cell wall. Inhibition of PBPs weakens the bacterial cell wall and leads to cell lysis. Sulbactam irreversibly inhibits β-lactamase enzymes generated by bacteria, preserving ampicillin activity and enhancing potency.
Product SpecificationsAmpicillin/sulbactam(2:1)SulacillinSulbactam-ampicillinmixt.
Formula: C25H31N3O9S2
MW: 581.66 g/mol
Storage/Handling: Store desiccated at -20°C.
PubChem Chemical ID: 119561
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