DOTMA
1,2-di-O-octadecenyl-3-trimethylammonium propane (chloride salt)
DOTMA is one of the two most widely used cationic lipids for gene transfection. DOTMA is an effective transfection agent in vitro and in vivo. DOTMA induces a positive charge on the surface of liposomes which promotes efficient interactions between the cell membrane and the liposome.
Ren T, Song YK, Zhang G, Liu D. Structural basis of DOTMA for its high intravenous transfection activity in mouse. Gene Ther. 2000 May;7(9):764-8. doi: 10.1038/sj.gt.3301153. PMID: 10822303.