Molecular Weight: 875.91Salt Form: TFAPurity: >95%Sequence (3-letter): Ac-Arg-Gly-Phe-Phe-Pro-AFCSequence (1-letter): Ac-RGFFP-AFCStorage: -20 °C or below
Ac-Arg-Gly-Phe-Phe-Pro-AFC is a fluorogenic substrate for cathepsin D. Cathepsin D is a lysosomal aspartyl protease whose role is to degrade and activate intracellular proteins including hormones, enzyme precursors, and growth factors. Over expression in tumors stimulates metastasis and considered a marker of poor prognosis in breast cancer.
Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.
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