N-oleoylglycine
N-oleoylglycine
N-oleoylglycine is thought to be a substrate for the peptide amidating enzyme, peptidylglycine alpha amidating monooxygenase (PAM), in the biosynthesis of oleoylamide.1 Recent evidence indicates that oleoylglycine possesses biologic activity independent of its conversion to oleamide. Also,increased availability of oleoylglycine as a potential substrate for PAMdoes not drive the biosynthesis of oleamide.2
1 Merkler, D.J., Merkler, K.A., Stern, W., Fleming, F.F. (1996) Fatty acid amide biosynthesis: a possible new role for peptidylglycine alpha-amidating enzyme and acyl-coenzyme A: glycine N-acyltransferase. Arch Biochem Biophys. 330:430-4.
2 Chaturvedi, S., Driscoll, W.J., Elliot, B.M., Faraday, M.M., Grunberg, N.E., Mueller, G.P. (2006) In vivo evidence that N-oleoylglycine acts independently of its conversion to oleamide. Prostaglandins Other Lipid Mediat.81:136-49.