N-palmitoylglycine
N-palmitoylglycine
The acyl amides are a family of endogenous lipids that act as potent modulators of pain and inflammation. The best characterized members of this family are the arachidonoyl amides, which includes N-arachidonoyl ethanolamide (AEA; anandamide). N-palmitoylglycine (PalGly) contains a 16-carbon saturated fatty acid that is amide-linked to glycine and is structurally similar to the phospholipid-derived N-acyl ethanolamines. Endogenously produced in rat skin and spinal cord, PalGly is present in 100-fold greater amounts in skin and 3-fold greater in brain compared to AEA.1
1 Rimmerman, N., Bradshaw, H.B., Hughes, H.V., Chen, J.S., Hu, S.S., McHugh, D., Vefring, E., Jahnsen, J.A., Thompson, E.L., Masuda, K., Cravatt, B.F., Burstein, S., Vasko, M.R., Prieto, A.L., O"Dell, D.K., Walker, J.M. (2008) N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons. Mol Pharmacol 74:213-224.
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