cis-4-methylsphingosine (cis-4M-Sph) is a synthetic sphingosine analogue that is readily taken up by cells and interacts with S1P receptors through its metabolite cis-4M-S1P in a manner similar to FTY720. cis-4M-Sph interacts primarilywith the S1P receptors S1P(2) and S1P(3), and only weakly with S1P(1). cis-4M-Sphinduces apoptosis of neuroblastoma cells.