CAS Number: 396716-14-6Molecular Weight: 1572.76Salt Form: TFAPurity: >95%Sequence (3-letter): Dabcyl-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-EDANSSequence (1-letter): Dabcyl-LAQAVRSSSR-EDANSStorage: -20 °C or below
Dabcyl-LAQAVRSSSR-EDANS is a fluorescence energy transfer (FRET) peptide substrate for tumor necrosis factor (TNF)-α convertase (TACE) (Km ~19 µM). TACE, also known as ADAM 17, cleaves TNF-α from the membrane to activate it. TACE cleaves the Ala-Val bond and the substrate can be used to screen for inhibitors.
Activity is quantified by release of fluorescent EDANS which excites at 365 nm and emits at 490 nm.
| Categories | Peptides |
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| Filter | Caspase, Enzyme Substrates |
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