17:0 Cyclic LPA
1-heptadecanoyl-glycero-2,3-cyclic-phosphate (ammonium salt)
Cyclic phosphatidic acid (cPA) is a naturally occurring analog of the growth factor-like phospholipid mediator, lysophosphatidic acid (LPA). The sn-2 hydroxy group of CPA forms a 5-membered ring with the sn-3 phosphate. cPA affects numerous cellular functions, including anti-mitogenic regulation of the cell cycle1, induction of stress fiber formation2, inhibition of tumor cell invasion and metastasis3, and regulation of differentiation and survival of neuronal cells4. Interestingly, many of these cellular responses caused by cPA oppose those of LPA despite the activation of apparently overlapping receptor populations.
You can find additional information on cPA at the following link:LIPID MAPS Lipidomics Gateway
1. Murakami-Murofushi, K., Kaji, K., Kano, K., Fukuda, M., Shioda, M., and Murofushi, H. (1993) Inhibition of cell proliferation by a unique lysophosphatidic acid, PHYLPA, isolated from Physarum polycephalum: signaling events of antiproliferative action by PHYLPA. Cell Struct. Funct. 18:363–370.
2. Fischer, D.L., Liliom, K., Guo, H., Nusser, N., Virag, T., Murakami-Murofushi, K., Kobayashi, S., Erickson, J.P., Sun, G., Miller, D.D., and Tigyi, G. (1998) Naturally occurring analogs of lysophosphatidic acid elicit different cellular responses through selective activation of multiple receptor subtypes.Mol. Pharmacol. 54:979–988.
3. Mukai, M., Imamura, F., Ayaki, M., Shinkai, K., Iwasaki, T., Murakami-Murofushi, K., Murofushi, H., Kobayashi, S., Yamamoto, T., Nakamura, H., and Akedo, H. (1999) Inhibition of tumor invasion and metastasis by a novel lysophosphatidic acid (cyclic LPA). Int. J. Cancer 81:918–922.
4. Fujiwara, Y., Sebok, A., Meakin, S., Kobayashi, T., Murakami-Murofushi, K., and Tigyi, G. (2003) Cyclic phosphatidic acid elicits neurotrophin-like actions in embryonic hippocampal neurons. J. Neurochem. 87:1272–1283.
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