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- 850522 | Facade®-EM: Two Dimensional Amphiphile
  3α-hydroxy-7α,12α-di-((O-ß-D-maltosyl)-2-hydroxyethoxy)-cholane
  Info
  Facade®-EM: Two Dimensional Amphiphile
  3α-hydroxy-7α,12α-di-((O-ß-D-maltosyl)-2-hydroxyethoxy)-cholane
  Facade®-EM: Order the Latest Two-Dimensional Amphiphile
  Facade®-EM (3α-hydroxy-7α,12α-di-((O-ß-D-maltosyl)-2-hydroxyethoxy)-cholane) is a two-dimensional amphiphile with hydrophobic and hydrophilic faces. With its divergence from the traditional one-dimensional polar-head/nonpolar-tail molecules, this new class of detergents has a superior ability to stabilize integral membrane proteins. Keep reading to learn more.
  How Do Detergents Relate to Protein Research?
  One of the main challenges in protein biochemistry is the study of membrane proteins. This is especially true when working outside of the parameters of the natural lipid environment. When conducting in vitro studies, researchers rely heavily on the solubilization of membrane proteins—which typically requires wisely-chosen solubilizing detergents and mixed lipid/detergent systems.
  The Application of Facade®EM
  Facade®EM (3α-hydroxy-7α,12α-di-((O-β-D-maltosyl)-2-hydroxyethoxy)-cholane) may be used in several ways.
  It can be used as a facial amphiphile detergent to purify protoxin-II (ProTx2)-voltage-sensor domain II (VSD2)-voltage-gated sodium (NavAb) channel. It can also be used as an additive in fluorescence quenching experiments of pentaene-SM 18, or to form isotropic bicelles with p75 for nuclear magnetic resonance (NMR) studies.
  Purchase High-Quality Detergents from Avanti Polar Lipids
  From unique detergents exclusive to Avanti to detergent kits and beyond, Avanti Polar Lipids has the products, services, and expertise you need to ensure the best results from your research—every time. Order Facade®EM here, or browse our entire catalog of detergents here.
  Data
  Hygroscopic
  No
  Light Sensitive
  No
  Molecular Formula
  C₅₂H₉₀O₂₅
  Percent Composition
  C 56.00%, H 8.13%, O 35.86%
  Purity
  >99%
  Stability
  1 Years
  Storage Temperature
  -20°C
  CAS Number
  1429405-95-7 CAS Registry Number is a Registered Trademark of the American Chemical Society
  FormulaWeight
  1115.256
  Exact Mass
  1114.577
  Synonyms
  FA-33α-hydroxy-7α,12α-di-((O-ß-D-maltopyranosyl)ethyloxy)-cholane
  Downloads
  ChemDraw File
  3D Structure
  Structure
  Technical Data Sheet
  Safety Data Sheet
  References
  Xu H, Li T, Rohou A, Arthur CP, Tzakoniati F, Wong E, Estevez A, Kugel C, Franke Y, Chen J, Ciferri C, Hackos DH, Koth CM, Payandeh J. Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell. 2019 Feb 7;176(4):702-715.e14. doi: 10.1016/j.cell.2018.12.018. Epub 2019 Jan 17.
  PubMed ID: 30661758
  Ho H, Miu A, Alexander MK, Garcia NK, Oh A, Zilberleyb I, Reichelt M, Austin CD, Tam C, Shriver S, Hu H, Labadie SS, Liang J, Wang L, Wang J, Lu Y, Purkey HE, Quinn J, Franke Y, Clark K, Beresini MH, Tan MW, Sellers BD, Maurer T, Koehler MFT, Wecksler AT, Kiefer JR, Verma V, Xu Y, Nishiyama M, Payandeh J, Koth CM. Structural basis for dual-mode inhibition of the ABC transporter MsbA. Nature. 2018 May;557(7704):196-201.
  PubMed ID: 29720648
  Lee, S.C., B.C. Bennett, W.X. Hong, Y. Fu, K.A. Baker, J. Marcoux, C.V. Robinson, A.B. Ward, J.R. Halpert, R.C. Stevens, C.D. Stout, M.J. Yeager, and Q. Zhang. (2013). Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins. Proc Natl Acad Sci U S A 110:E1203-11. [PubMed]
  PubMed ID: 23479627
  Zhang, Q., X. Ma, A. Ward, W.X. Hong, V.P. Jaakola, R.C. Stevens, M.G. Finn, and G. Chang. (2007) Designing facial amphiphiles for the stabilization of integral membrane proteins. Angew Chem Int Ed Engl 46:7023-5. [PubMed]
  PubMed ID: 17691085
  Kot EF, Goncharuk SA, Arseniev AS, Mineev KS. Phase Transitions in Small Isotropic Bicelles. Langmuir. 2018 Mar 6. doi: 10.1021/acs.langmuir.7b03610.
  PubMed ID: 29486112
  Certificates of Analysis
  Certificate of Analysis(Lot No. 850522P-1G-A-014and 5702PQA014)
  
  Certificate of Analysis(Lot No. 850522P-200MG-A-014and 5702PNA014)
  
  Certificate of Analysis(Lot No. 850522P-25MG-A-014and 5702PJA014)
  
  Certificate of Analysis(Lot No. 850522P-1G-A-016and 5702PQA016)
  
  Certificate of Analysis(Lot No. 850522P-25MG-A-016and 5702PJA016)
  
  Certificate of Analysis(Lot No. 850522P-200MG-A-016and 5702PNA016)
  
  Certificate of Analysis(Lot No. 850522P-1G-B-016and 5702PQB016)
  
  Certificate of Analysis(Lot No. 850522P-200MG-A-016_5702PNA016_180924_092430and 5702PNA016)
  
  Certificate of Analysis(Lot No. 850522P-1G-A-017and 5702PQA017)
  
  Certificate of Analysis(Lot No. 850522P-1G-C-016and 5702PQC016)
  
  Certificate of Analysis(Lot No. 850522P-25MG-A-017and 5702PJA017)
  
  Certificate of Analysis(Lot No. 850522P-200MG-B-010and 5702PNB010)
  
  Certificate of Analysis(Lot No. 850522P-200MG-A-018and 5702PNA018)
  
  Certificate of Analysis(Lot No. 850522P-1G-A-018and 5702PQA018)
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avanti polar lipids/Facade®-EM: Two Dimensional Amphiphile/25mg/850522P-25mg

850522 | Facade®-EM: Two Dimensional Amphiphile

3α-hydroxy-7α,12α-di-((O-ß-D-maltosyl)-2-hydroxyethoxy)-cholane

Facade®-EM: Two Dimensional Amphiphile

3α-hydroxy-7α,12α-di-((O-ß-D-maltosyl)-2-hydroxyethoxy)-cholane

Facade®-EM: Order the Latest Two-Dimensional Amphiphile

How Do Detergents Relate to Protein Research?

The Application of Facade®EM

Purchase High-Quality Detergents from Avanti Polar Lipids

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