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咨询顾问Facade®-EM: Two Dimensional Amphiphile
3α-hydroxy-7α,12α-di-((O-ß-D-maltosyl)-2-hydroxyethoxy)-cholane
Facade®-EM: Order the Latest Two-Dimensional Amphiphile
Facade®-EM (3α-hydroxy-7α,12α-di-((O-ß-D-maltosyl)-2-hydroxyethoxy)-cholane) is a two-dimensional amphiphile with hydrophobic and hydrophilic faces. With its divergence from the traditional one-dimensional polar-head/nonpolar-tail molecules, this new class of detergents has a superior ability to stabilize integral membrane proteins. Keep reading to learn more.
How Do Detergents Relate to Protein Research?
One of the main challenges in protein biochemistry is the study of membrane proteins. This is especially true when working outside of the parameters of the natural lipid environment. When conducting in vitro studies, researchers rely heavily on the solubilization of membrane proteins—which typically requires wisely-chosen solubilizing detergents and mixed lipid/detergent systems.
The Application of Facade®EM
Facade®EM (3α-hydroxy-7α,12α-di-((O-β-D-maltosyl)-2-hydroxyethoxy)-cholane) may be used in several ways.
It can be used as a facial amphiphile detergent to purify protoxin-II (ProTx2)-voltage-sensor domain II (VSD2)-voltage-gated sodium (NavAb) channel. It can also be used as an additive in fluorescence quenching experiments of pentaene-SM 18, or to form isotropic bicelles with p75 for nuclear magnetic resonance (NMR) studies.
Purchase High-Quality Detergents from Avanti Polar Lipids
From unique detergents exclusive to Avanti to detergent kits and beyond, Avanti Polar Lipids has the products, services, and expertise you need to ensure the best results from your research—every time. Order Facade®EM here, or browse our entire catalog of detergents here.
