n-dodecyl-ß-D-maltoside (DDM)
n-dodecyl-β-D-maltopyranoside
DDM is the most widely used detergent for the isolation and purification of GPCR’s.
In addition, LacY likely favors a higher-energy intermediate periplasmic-open conformation in situ, but collapses to a lower-energy periplasmic-closed conformation in DDM after purification. It is interesting to note that the branched-chain maltoside detergents stabilize LacY in the membrane-embedded form (see Related Products).