N-P Tyrosine PA
N-palmitoyl-tyrosine phosphoric acid (ammonium salt)
Lysophosphatidic acid (LPA) receptor modulators include N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid. N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid are competitive inhibitors of the LPA receptor in Xenopus oocytes [Neidlinger et al, 2006; Liliom et al, 1996]. However, in mammalian cells, N-palmitoyl-tyrosine phosphoric acid may act as an agonist for the LPA receptor [An et al, 1998]. LPA is a lipid mediator that acts similar to growth factors through G-protein coupled plasma membrane receptors [Neidlinger et al, 2006; Liliom et al, 1996; Bittman et al, 1996; An et al, 1998]. LPA may play a role in platelet aggregation, smooth muscle contraction, vasoactive changes, cytoskeletal reorganization and cell proliferation [Neidlinger et al, 2006].
Product use:
N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acid can be used for cell studies. An et al. dissolved these lipids in 0.1 mL PBS containing 0.1 mg/mL human serum albumin before adding to cells [An et al, 1998]. In X. laevis studies, these LPA inhibitors were dissolved in DMSO at 1 mM and filtered through a 0.45 mM membrane filter before injection [Liliom et al, 1996].
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