N-P Serine PA
N-palmitoyl-serine phosphoric acid (ammonium salt)
Lysophosphatidic acid (LPA) receptor modulators include N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid. N-palmitoyl serine phosphoric acid is a competitive inhibitor of the LPA receptor in Xenopus oocytes [Neidlinger et al, 2006; Liliom et al, 1996]. However, in mammalian cells, N-palmitoyl-serine phosphoric acid may act as an agonist for the LPA receptor [Hooks et al, 1998; An et al, 1998]. LPA is a lipid mediator that acts similar to growth factors through G-protein coupled plasma membrane receptors [Neidlinger et al, 2006; Liliom et al, 1996; Hooks et al, 1998; An et al, 1998; Jan et al, 2003]. LPA may play a role in platelet aggregation, smooth muscle contraction, vasoactive changes, cytoskeletal reorganization and cell proliferation [neidlinger et al, 2006]. N-palmitoyl serine phosphoric acid may also play a role in signal transduction in mammalian cells by increasing intracellular calcium [An et al, 1998; Jan et al, 2003].
Product use:
A range of 0.1-20 mM of N-palmitoyl serine phosphoric acid can be used for cell studies. Make a stock solution of 5 mM in DMSO and store at -20°C. Diluted N-palmitoyl serine phosphoric acid can be directly added to the study medium [Jan et al, 2003]. An et al. dissolved N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acid in 0.1 mL PBS containing 0.1 mg/mL human serum albumin before adding to cells [An et al, 1998]. In X. laevis studies, these LPA inhibitors were dissolved in DMSO at 1 mM and filtered through a 0.45 mM membrane filter before injection [Liliom et al, 1996].
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