CAS Number: 133407-83-7Molecular Weight: 475.3Salt Form: N/APurity: >95%Sequence (3-letter): Z-Leu-Leu-Nle-CHOSequence (1-letter): Z-LL(Nle)-CHOStorage: -20 °C or belowSolubility: DMSO > 1 mg/mL
Gamma Secretase Inhibitor, sequence Z-Leu-Leu-Nle-CHO (Z-Leu-Leu-Nle-al), is a leupeptin analog which inhibits gamma secretase. Gamma secretase is a membrane associated protein complex consisting of presenilin, nicastrin, Aph-1, and Pen-2. It catalyzes the cleavage of Notch and Beta Amyloid proteins and is implicated in Alzheimer’s disease.
Categories | Peptides |
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Filter | Central Nervous System, Inhibitor |
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