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PotentandselectiveirreversibleFAAHinhibitor(IC50=7.2nM).SelectiveforFAAHoverapanelofotherserinehydrolases.Exhibitsefficacyinaratinflammatorypainmodel.Orallybioavailableandbrainpenetrant.
SoldforresearchpurposesunderagreementfromPfizerInc
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight455.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Referencesarepublicationsthatsupporttheproducts'biologicalactivity.
Ahnetal(2011)MechaNISTicandpharmacologicalcharacterizationofPF-04457845:ahighlypotentandselectivefattyacidamidehydrolaseinhibitorthatreducesinflammatoryandnoninflammatorypain.J.Pharmacol.Exp.Ther.338114PMID:21505060
Johnsonetal(2011)DiscoveryofPF-04457845:ahighlypotent,orallybioavailable,andselectiveureaFAAHinhibitor.ACSMed.Chem.Lett.291PMID:21666860
Keywords:PF04457845,supplier,PF04457845,FAAH,fatty,acid,amide,hydrolase,inhibitors,inhibits,potent,selective,irreversible,orally,bioavailalbe,brain,penetrant,Fatty,Acid,Amide,Hydrolase,(FAAH),Fatty,Acid,Amide,Hydrolase,(FAAH),TocrisBioscience
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