BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PotentTNF-αinhibitor(IC50=13nM).AlsopotentlyinhibitsIL-2(EC50=8nM).Thalidomidederivative.Bindscereblonandinhibitsitsubiquitination.ExhibitsantiproliferativeeffectsinaNamalwalymphomacellline.Antiangiogenic.
TechnicalData
| M.Wt | 273.24 |
| Formula | C13H11N3O4 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 19171-19-8 |
| PubChemID | 134780 |
| InChIKey | UVSMNLNDYGZFPF-UHFFFAOYSA-N |
| Smiles | NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 27.32 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight273.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 3.66mL | 18.3mL | 36.6mL |
| 5mM | 0.73mL | 3.66mL | 7.32mL |
| 10mM | 0.37mL | 1.83mL | 3.66mL |
| 50mM | 0.07mL | 0.37mL | 0.73mL |
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