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Tocris/ELA-32 (human)/6291/100U/100 ug
  • Tocris/ELA-32 (human)/6291/100U/100 ug

Tocris/ELA-32 (human)/6291/100U/100 ug

价格: ¥2220.00 市场价: 3700.00
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货号: 6291
品牌: Tocris
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    • Description:Potent,highaffinityapelinreceptoragoNIST;stimulatesangiogenesis
      AlternativeNames:APJearlyendogenousligand,Apela,Elabela,Toddler
      BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

      BiologicalActivity

      Potent,highaffinityapelinreceptoragonist(IC50=0.27nM;Kd=0.51nM).ExhibitsnobindingGPR15andGPR25.ActivatesthePI3K/AKTpathwayandpromotesself-renewalofhESCsviacell-cycleprogressionandproteintranslation.AlsopotentiatestheTGFβpathway,priminghESCstowardtheendodermlineage.StimulatesangiogenesisinHUVECcells.Relaxesmouseaorticvessels.FunctionsasananorexigenichormonethroughactivationoftheAVPandCRHneuronsinthePVN.Negativecontrol(Cat.No.6292)available.

      LicensingInformation

      SoldunderagreementfromtheAgencyforScience,TechnologyandResearch(A*STAR),ETPL,andaffiliatesincludingtheInstituteofMedicalBiology.

      TechnicalData

      M.Wt3967.8
      FormulaC170H289N63O39S4
      SequenceQRPVNLTMRRKLRKHNCLQRRCMPLHSRVPFP

      (Modifications:Disulfidebridge:17-22)

      StorageStoreat-20°C
      CASNumber1680205-79-1
      InChIKeyQSDOQAYDPQAWEK-HLMHHTBMNA-N
      Smiles[H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(O)=O

      Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

      AllTocrisproductsareintendedforlaboratoryresearchuseonly.

      SolubilityData

      SolubilitySolubleto1mg/mlinwater

      PreparingStockSolutions

      Thefollowingdataisbasedontheproductmolecularweight3967.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

      Concentration/SolventVolume/Mass1mg5mg10mg
      1mM0.25mL1.26mL2.52mL
      5mM0.05mL0.25mL0.5mL
      10mM0.03mL0.13mL0.25mL
      50mM0.01mL0.03mL0.05mL