Tocris/JNJ 55511118/6278/5/5 mg188bio精品生物—专注于实验室精品爆款的电商平台

BiologicalActivity

HighaffinityandselectivenegativemodulatorofAMPAreceptorscontainingTARP-γ8(K_i=26nM).Exhibits<50%bindingagainstapanelof52receptors,ionchannelsandtransporters(except5HT_2Bandmelatoninreceptors78%and57%,respectively).AlsodisplaysminimalactivityagainstotherTARP-lessAMPARsandAMPARscoexpressedwithotherTARPsorCNIH2.Orallybioavailableandbrainpenetrant.Anticonvulsant.

LicensingInformation

SoldwiththepermissionofJanssenPharmaceuticaN.V.

TechnicalData

M.Wt	328.67
Formula	C₁₄H₈ClF₃N₂O₂
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	2036081-86-2
Smiles	ClC1=CC=CC(OC(F)(F)F)=C1C2=CC=C3NC(NC3=C2)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	32.87	100
	ethanol	32.87	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight328.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.04mL	15.21mL	30.43mL
5mM	0.61mL	3.04mL	6.09mL
10mM	0.3mL	1.52mL	3.04mL
50mM	0.06mL	0.3mL	0.61mL

MolarityCalculator

Calculatethemass,volume,orconcentrationrequiredforasolution.

ReconstitutionCalculator

Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.

Volume(toaddtovial)

DilutionCalculator

Calculatethedilutionrequiredtoprepareastocksolution.