BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Receptorforadvancedglycationendproducts(RAGE)antagonist.BlocksS100P,S100A4andHMGB-1mediatedRAGEactivationinvitroandinvivo.Inhibitsgrowthandmetastasisofratgliomatumors.ReducescellgrowthandRAGE-mediatedNF-κBactivityinhumanPDACcelllines.InhibitseffectsofTDIexposureinBALB/cmice.
TechnicalData
| M.Wt | 1272.56 |
| Formula | C57H101N13O17S |
| Sequence | ELKVLMEKEL (Modifications:Glu-1=N-terminalAc,Leu-10=C-terminalamide) |
| Storage | Storeat-20°C |
| CASNumber | 1092460-91-7 |
| PubChemID | 127021052 |
| InChIKey | UPCWJIBXKJZZLN-YZLORNOTNA-N |
| Smiles | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(C)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1272.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 0.79mL | 3.93mL | 7.86mL |
| 5mM | 0.16mL | 0.79mL | 1.57mL |
| 10mM | 0.08mL | 0.39mL | 0.79mL |
| 50mM | 0.02mL | 0.08mL | 0.16mL |
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