Description:Polyeneantibiotic;inhibitsformationofpathologicalisoformofprionprotein
ChemicalName:(3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,16,27-Octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Polyeneantibiotic.Bindssterolsinfungalmembranes.Alsoinhibitsformationofthepathologicalformofprionprotein(PrP-res)fromthenormalmembrane-bound(PrP-sen)form.Alsofluorescentcholesterolstain.
TechnicalData
| M.Wt | 654.83 |
| Formula | C35H58O11 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 480-49-9 |
| PubChemID | 6433553 |
| InChIKey | IMQSIXYSKPIGPD-ZPXVTHDFSA-N |
| Smiles | C[C@@H](O1)[C@@H](O)/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)[C@]([C@H](O)CCCCC)([H])C1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 3.27 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight654.83.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 1.53mL | 7.64mL | 15.27mL |
| 5mM | 0.31mL | 1.53mL | 3.05mL |
| 10mM | 0.15mL | 0.76mL | 1.53mL |
| 50mM | 0.03mL | 0.15mL | 0.31mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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