Tocris/FPS ZM1/6237/10/10 mg188bio精品生物—专注于实验室精品爆款的电商平台

BiologicalActivity

Highaffinityantagonistofthereceptorforadvancedglycationendproducts(RAGE)(K_i=25nM).BlocksAβbindingtotheVdomainofRAGEandinhibitsAβ40-andAβ42-inducedcellularstressinRAGE-expressingcellsinvitroandinthemousebraininvivo.Blocksβ-secretaseactivity,Aβproduction,microgliaactivationandneuroinflammationinvivo.BBBpermeable.

TechnicalData

M.Wt	327.85
Formula	C₂₀H₂₂ClNO
Storage	Storeat-20°C
Purity	≥99%(HPLC)
CASNumber	945714-67-0
PubChemID	24752728
InChIKey	XDFKWGIBQMHSOH-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C(N(C2CCCCC2)CC3=CC=CC=C3)=O)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	32.78	100
	ethanol	32.78	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight327.85.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.05mL	15.25mL	30.5mL
5mM	0.61mL	3.05mL	6.1mL
10mM	0.31mL	1.53mL	3.05mL
50mM	0.06mL	0.31mL	0.61mL

MolarityCalculator

Calculatethemass,volume,orconcentrationrequiredforasolution.

ReconstitutionCalculator

Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.

Volume(toaddtovial)

DilutionCalculator

Calculatethedilutionrequiredtoprepareastocksolution.