BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PotentandselectivehepatitisBvirusreversetranscriptaseinhibitor(EC50=3nM);guanineanalog.InhibitshepatitisBvirusreplicationinHepG2.2.15cells.DisplaysselectivelyoverHCMV,HSV-1,VZV,HIVandinfluenza(EC50valuesare15,32,30-60,>10and>80μMrespectively).Orallybioavailable.
TechnicalData
| M.Wt | 277.28 |
| Formula | C12H15N5O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 142217-69-4 |
| PubChemID | 153941 |
| InChIKey | QDGZDCVAUDNJFG-FXQIFTODSA-N |
| Smiles | O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)C3=C)C=N2)NC(N)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 27.73 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight277.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 3.61mL | 18.03mL | 36.06mL |
| 5mM | 0.72mL | 3.61mL | 7.21mL |
| 10mM | 0.36mL | 1.8mL | 3.61mL |
| 50mM | 0.07mL | 0.36mL | 0.72mL |
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