Description:STAT3inhibitor;activeinvivo
ChemicalName:(4S,5aR,7aR,7bS)-5,5a,6,7,7a,7b-Hexahydro-7b-hydroxy-4-methylindeno[1,7-bc]furan-2(4H)-one
Purity:≥95%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
STAT3inhibitor.IrreversIBLybindsSTAT3andinhibitsbindingtoDNA.InhibitsIL-6-dependentJAK/STATsignaling.Inducescell-cyclearrestinG2/Mphaseandapoptosisinandrogen-insensitiveprostatecancercellsviaactivationofATM/ATRpathway.AlsodestABIlizesmicrotubulesandinhibitscellmigration.Exhibitsanticancereffectsinamousetumorxenograftmodel.
TechnicalData
| M.Wt | 194.23 |
| Formula | C11H14O3 |
| Storage | Storeat-20°C |
| Purity | ≥95%(HPLC) |
| CASNumber | 133613-71-5 |
| PubChemID | 3698011 |
| InChIKey | SOIISBQQYAGDKM-UHFFFAOYSA-N |
| Smiles | [H][C@@]12CC[C@]3(OC(C([C@@]23O)=C[C@H](C1)C)=O)[H] |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 0.97 | 5 |
| ethanol | 0.97 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight194.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 5.15mL | 25.74mL | 51.49mL |
| 5mM | 1.03mL | 5.15mL | 10.3mL |
| 10mM | 0.51mL | 2.57mL | 5.15mL |
| 50mM | 0.1mL | 0.51mL | 1.03mL |
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