Tocris/MS 275/6208/10/10 mg188bio精品生物—专注于实验室精品爆款的电商平台

BiologicalActivity

ClassIHDACinhibitor(IC₅₀valuesare0.18,0.74,44.9and>100μMforHDAC1,3,8and6,respectively).Exhibitsantiproliferativeeffectsandinducesapoptosisinarangeoftumorcelllinesinvitroandinvivo.Increasesestrogenreceptorα-andaromataseexpressioninbreastcancercells.InhibitsPCB-inducedneuronalcelldeathbypreventingHDAC3bindingandhistonedeacetylationwithinthesynapsin-1promoter.

TechnicalData

M.Wt	376.41
Formula	C₂₁H₂₀N₄O₃
Storage	Storeat-20°C
Purity	≥99%(HPLC)
CASNumber	209783-80-2
PubChemID	4261
InChIKey	INVTYAOGFAGBOE-UHFFFAOYSA-N
Smiles	O=C(C1=CC=C(C=C1)CNC(OCC2=CN=CC=C2)=O)NC3=CC=CC=C3N

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	37.64	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight376.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.66mL	13.28mL	26.57mL
5mM	0.53mL	2.66mL	5.31mL
10mM	0.27mL	1.33mL	2.66mL
50mM	0.05mL	0.27mL	0.53mL

MolarityCalculator

Calculatethemass,volume,orconcentrationrequiredforasolution.

ReconstitutionCalculator

Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.

Volume(toaddtovial)

DilutionCalculator

Calculatethedilutionrequiredtoprepareastocksolution.