Tocris/TM 5441/6194/10/10 mg188bio精品生物—专注于实验室精品爆款的电商平台

BiologicalActivity

Plasminogenactivatorinhibitor-1(PAI-1)inhibitor(IC₅₀=3.58-60.3μM).Increasesapoptosisinhumancancercelllines.ReducessenescenceandincreasesLifespaninmousemodelsofageing(kl/kl).InhibitsL-NAME(Cat.No.0665)inducedsystolicbloodpressureincreases,telomerelengthreductionandcardiachypertrophyinmice.Renoprotective.Orallybioavailable.

TechnicalData

M.Wt	450.8
Formula	C₂₁H₁₆ClN₂NaO₆
Storage	Storeat+4°C
Purity	≥98%(HPLC)
PubChemID	44250349
InChIKey	RDKPAESSEMYFJL-UHFFFAOYSA-M
Smiles	O=C(C1=C(C=CC(Cl)=C1)NC(COCC(NC2=CC=CC(C3=COC=C3)=C2)=O)=O)O[Na]

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	45.08	100
	water	2.25	5mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight450.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.22mL	11.09mL	22.18mL
5mM	0.44mL	2.22mL	4.44mL
10mM	0.22mL	1.11mL	2.22mL
50mM	0.04mL	0.22mL	0.44mL

MolarityCalculator

Calculatethemass,volume,orconcentrationrequiredforasolution.

ReconstitutionCalculator

Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.

Volume(toaddtovial)

DilutionCalculator

Calculatethedilutionrequiredtoprepareastocksolution.