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当前位置： Tocris >>> Tocris/TM 5441/6194/10/10 mg

Tocris/TM 5441/6194/10/10 mg

Tocris/TM 5441/6194/10/10 mg

价格: ¥2268.00 市场价: 3780.00

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货号: 6194

品牌: Tocris

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- Description:Plasminogenactivatorinhibitor-1(PAI-1)inhibitor
  ChemicalName:5-Chloro-2-[[2-[2-[[3-(3-furanyl)phenyl]amino]-2-oxoethoxy]acetyl]amino]benzoicacidsodiumsalt
  Purity:≥98%(HPLC)
  BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
  BiologicalActivity
  Plasminogenactivatorinhibitor-1(PAI-1)inhibitor(IC₅₀=3.58-60.3μM).Increasesapoptosisinhumancancercelllines.ReducessenescenceandincreasesLifespaninmousemodelsofageing(kl/kl).InhibitsL-NAME(Cat.No.0665)inducedsystolicbloodpressureincreases,telomerelengthreductionandcardiachypertrophyinmice.Renoprotective.Orallybioavailable.
  TechnicalData
  M.Wt 450.8
  Formula C₂₁H₁₆ClN₂NaO₆
  Storage Storeat+4°C
  Purity ≥98%(HPLC)
  PubChemID 44250349
  InChIKey RDKPAESSEMYFJL-UHFFFAOYSA-M
  Smiles O=C(C1=C(C=CC(Cl)=C1)NC(COCC(NC2=CC=CC(C3=COC=C3)=C2)=O)=O)O[Na]
  Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
  AllTocrisproductsareintendedforlaboratoryresearchuseonly.
  SolubilityData
  Solvent MaxConc.mg/mL MaxConc.mM
  Solubility
  DMSO 45.08 100
  water 2.25 5mMwithgentlewarming
  PreparingStockSolutions
  Thefollowingdataisbasedontheproductmolecularweight450.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
  Concentration/SolventVolume/Mass 1mg 5mg 10mg
  1mM 2.22mL 11.09mL 22.18mL
  5mM 0.44mL 2.22mL 4.44mL
  10mM 0.22mL 1.11mL 2.22mL
  50mM 0.04mL 0.22mL 0.44mL