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Tocris/TH 1020/6191/10/10 mg
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Tocris/TH 1020/6191/10/10 mg

价格: ¥1500.00 市场价: 2500.00
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货号: 6191
品牌: Tocris
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    • Description:Toll-likereceptor(TLR)5/FlagellincomplexantagoNIST
      ChemicalName:4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine
      Purity:≥98%(HPLC)
      BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

      BiologicalActivity

      Toll-likereceptor(TLR)5/Flagellincomplexantagonist(IC50=0.85μM).CompeteswithflagellinforTLR5bindingtoinhibittheTLR5:flagellininteractionandsubsequentdownstreamTNF-αsecretion.

      TechnicalData

      M.Wt453.54
      FormulaC23H15N7S2
      StorageStoreat+4°C
      Purity≥98%(HPLC)
      CASNumber1841460-82-9
      PubChemID124203921
      InChIKeyCBBXTGWSGPEJEE-UHFFFAOYSA-N
      SmilesN1(C(SC2=C3SC4=NC=CC=C4C3=NC=N2)=NN=C1C5=CC=NC=C5)CC6=CC=CC=C6

      Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

      AllTocrisproductsareintendedforlaboratoryresearchuseonly.

      SolubilityData

      SolventMaxConc.mg/mLMaxConc.mM
      Solubility
      DMSO2.275mMwithgentlewarming

      PreparingStockSolutions

      Thefollowingdataisbasedontheproductmolecularweight453.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

      Concentration/SolventVolume/Mass1mg5mg10mg
      1mM2.2mL11.02mL22.05mL
      5mM0.44mL2.2mL4.41mL
      10mM0.22mL1.1mL2.2mL
      50mM0.04mL0.22mL0.44mL