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Tocris/VH 298/6156/10/10 mg
  • Tocris/VH 298/6156/10/10 mg

Tocris/VH 298/6156/10/10 mg

价格: ¥2940.00 市场价: 4900.00
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货号: 6156
品牌: Tocris
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    • Description:High-affinityinhibitorofVHL
      ChemicalName:(2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
      Purity:≥98%(HPLC)
      BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

      BiologicalActivity

      High-affinityinhibitorofE3ubiquitinligaseVHL(Kd=80-90nM).BlocksinteractionbetweenVHLandHIF-αdownstreamofHIF-αhydroxylation,initiatinghypoxicresponse.Resultsintime-andconcentration-dependentaccumulationofhydroxylatedHIF-α,andupregulatesmRNAandproteinlevelsofHIFtargetgenes.Cellpermeable.NegativecontrolcisVH298alsoavailable.

      LicensingInformation

      SoldunderlicencefromtheUniversityofDundee

      ExternalPortalInformation

      Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofVH298isreviewedontheChemicalProbeswebsite.

      TechnicalData

      M.Wt523.65
      FormulaC27H33N5O4S
      StorageStoreat-20°C
      Purity≥98%(HPLC)
      PubChemID122199236
      InChIKeyNDVQUNZCNAMROD-RZUBCFFCSA-N
      SmilesO=C(N[C@@H](C(C)(C)C)C(N1C[C@@H](C[C@H]1C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)O)=O)C4(C#N)CC4

      Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

      AllTocrisproductsareintendedforlaboratoryresearchuseonly.

      SolubilityData

      SolventMaxConc.mg/mLMaxConc.mM
      Solubility
      DMSO52.37100
      ethanol52.37100

      PreparingStockSolutions

      Thefollowingdataisbasedontheproductmolecularweight523.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

      Concentration/SolventVolume/Mass1mg5mg10mg
      1mM1.91mL9.55mL19.1mL
      5mM0.38mL1.91mL3.82mL
      10mM0.19mL0.95mL1.91mL
      50mM0.04mL0.19mL0.38mL