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Tocris/LDN 214117/6152/50/50 mg
  • Tocris/LDN 214117/6152/50/50 mg

Tocris/LDN 214117/6152/50/50 mg

价格: ¥9540.00 市场价: 15900.00

货号: 6152/50
品牌: Tocris
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    • Description:PotentandselectiveALK2inhibitor
      ChemicalName:1-[4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]piperazine
      Purity:≥98%(HPLC)
      BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

      BiologicalActivity

      PotentandselectiveinhibitoroftypeIbonemorphogenicprotein(BMP)receptorALK2(IC50=24nM).ShowspreferenceforALK1andALK2overALK3and164-foldselectivityforBMP6inhibition(IC50=100nM)overTGF-β1.ExhibitsimprovedkinomeselectivityoverK02288(Cat.No.4986)andlowcytotoxicity.

      LicensingInformation

      SoldforresearchpurposesunderexclusiveagreementfromTheBrighamandWomen"sHospitalInc.USpatent14/776,302

      TechnicalData

      M.Wt419.52
      FormulaC25H29N3O3
      StorageStoreat-20°C
      Purity≥98%(HPLC)
      CASNumber1627503-67-6
      PubChemID91754554
      InChIKeyBHUXVRVMMYAXKN-UHFFFAOYSA-N
      SmilesCOC1=CC(C2=C(N=CC(C3=CC=C(N4CCNCC4)C=C3)=C2)C)=CC(OC)=C1OC

      Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

      AllTocrisproductsareintendedforlaboratoryresearchuseonly.

      SolubilityData

      SolventMaxConc.mg/mLMaxConc.mM
      Solubility
      DMSO41.95100
      ethanol41.95100

      PreparingStockSolutions

      Thefollowingdataisbasedontheproductmolecularweight419.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

      Concentration/SolventVolume/Mass1mg5mg10mg
      1mM2.38mL11.92mL23.84mL
      5mM0.48mL2.38mL4.77mL
      10mM0.24mL1.19mL2.38mL
      50mM0.05mL0.24mL0.48mL

      ProductDatasheets

      CertificateofAnalysis/ProductDatasheet
      SafetyDatasheet

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