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Tocris/Zoledronic Acid/6111/50/50 mg

价格: ¥3540.00 市场价: 5900.00

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货号: 6111/50

品牌: Tocris

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Description: Potent farnesyl diphosphate (FPP) synthase inhibitor

Alternative Names: Zometa

Chemical Name: [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC₅₀ = 20 nM). Inhibits osteoclast-mediated bone resorption. Also inhibits Ras signaling and tumor growth, and induces apoptosis in pancreatic cancer cells. Reverses epithelial-mesenchymal transition and inhibits breast cancer cell renewal via inactivation of NF-κB.

Technical Data

M. Wt	272.09
Formula	C₅H₁₀N₂O₇P₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	118072-93-8
PubChem ID	68740
InChI Key	XRASPMIURGNCCH-UHFFFAOYSA-N
Smiles	OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	0.68	2.5
	1.1eq. NaOH	13.6	50

Preparing Stock Solutions

The following data is based on the product molecular weight 272.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.68 mL	18.38 mL	36.75 mL
5 mM	0.74 mL	3.68 mL	7.35 mL
10 mM	0.37 mL	1.84 mL	3.68 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Schech et al (2013) Zoledronic acid reverses the epithelial-mesenchymal transition and inhibits self-renewal of breast cancer cells through inactivation of NF-κB. Mol.Cancer Ther. 12 1356 PMID: 23619300

Tassone et al (2003) Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. Br.J.Cancer 88 1971 PMID: 12799645

Dunford et al (2001) Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J.Pharmacol.Exp.Ther. 296 235 PMID: 11160603

Keywords: Zoledronic Acid, supplier, bisphosphonate, NF-KB, NF-kappaB, NF-κB, signaling, inhibitors, inhibits, potent, FPP, synthase, farnesyl, diphosphate, Ras, Zometa, Other, Synthases/Synthetases, NF-kB/IkB, G, Proteins, (Small), Cancer, Stem, Cells, Other, Synthases/Synthetases, Tocris Bioscience

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