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HighaffinityfluorescentlytaggedaptamerforCD133(extracellulardomaineepitope)(Kdvaluesare52.3and145.1nMinHep3BandHT29cells,respectively).EfficientlyinternalizeduponbindingtoCD133.Exhibitssuperiorpenetrationoftumorspherescomparedwithanantibodytothesametarget.
Foroptimalbindingaptamersrequirerefoldingintotheirtertiarystructurepriortouse.Pleaserefertotheaccompanyingrefoldingprotocol.
Soldunderlicensefromthepatentholder,DeakinUniversity.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
PleaserefertothesesolubilityguidelinesforCD133-B19,5'-DY647(Cat.No.6104).
Thefollowingdataisbasedontheproductmolecularweight6847.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Referencesarepublicationsthatsupporttheproducts'biologicalactivity.
Shigdaretal(2013)RNAaptamerstargetingcancerstemcellMarkerCD133.CancerLett.33084PMID:23196060
Keywords:CD133-B19,5'-DY647,supplier,CD133-B19-5-DY647,Aptamers,CD133,extracellular,domain,epitope,fluorescent,high,affinity,Prominin-1,Fluorescent,Probes,Cancer,Stem,Cells,Aptamers,Aptamers,TocrisBioscience
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