"Alpha2A,2B,and2CadrenergicreceptorsareseventransmembranereceptorsthatcoupletoinhibitoryG-proteins.Alpha2ChasawidedistributionpatternintheCNS.Onneurons,Alpha2adrenergicreceptors(alpha2ARs)arelocatedonbothpre-andpostsynapticdomainswheretheymediateaninhibitoryroleinthecentralandperipheralnervoussystem.Alpha2ChasawidedistributionpatternintheCNS.Atthespinalcordlevelthevastmajorityofalpha2Cisnotofprimaryafferentorigin;however,asmallfractionofneuronsinDRGdoexpressmRNAforalpha2Candharbortheprotein.Colocalizationhasbeenobservedbetweenalpha2Candenkephalininthespinalcorddorsalhorn,suggestingthatalpha2Cmaybeexpressedbyasubsetofspinalinterneurons.Thedistributionpatternofalpha2Csuggestsfunctionsatseverallevelsinthebrain.Antibodyshowedpositivestaininginratspinalcorddorsalhorn,ventralhornmotorneuronsandretina."
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