Firstpurifiedfromclamganglia,FMRFamide(Phe-Met-Arg-Phe-NH2)isexpressedinbothinvertebratesandvertebrates.itshasbeenshowntoservevariousfunctionsinthemammaliannervoussystemincludinginhibitionofmorphine-inducedfeeding,behavioraleffectswhenadmiNISTeredintrathecally,andtohaveamnesiceffectsinrodents.Morerecently,FMRFamidehasbeenshowntopotentiateprotoncurrentsandasuggestedmodeofactionisthroughmodulationofASIC1andASIC3.
Specifications: