Lipotropinisahormoneproducedbythecleavageofpro-opiomelanocortin(POMC).Theanteriorpituitaryglandproducesthepro-hormonePOMC,whichundergoescleavagetoadrenocorticotropin(ACTH)andβ-lipotropin(β-LPH)whichisa90aminoacidpolypeptidethatisthecarboxy-terminalfragmentofPOMC.Itisthepredominantopioidpeptideofthehumanpituitaryandratparsdistalisandispresentinconcentrationsessentiallyequimolarwithcorticotropin.Itstimulatesmelanocytestoproducemelanin,andcanalsobecleavedintosmallerpeptides.Inhumans,γ-lipotropin,α-MSH,β-MSH,γ-MSH,α-endorphin,ß-endorphin,γ-endorphin,andmet-enkephalinareallpossIBLefragmentsofbeta-lipotropin.Beta-lipotropinalsoperformslipid-mobilizingfunctionssuchaslipolysisandsteroidogenesis.
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