Metabotropicglutamatereceptors(mGluRs)areG-proteincoupledreceptorsactivatedbyglutamate.Basedonsequencesimilarity,transductionmechanismsandagoNISTpotencies,mGluRsaresuBDividedintothreegroups:mGluR1/mGluR5,mGluR2/mGluR3,andmGluR4/mGluR6/mGluR7/mGluR8.mGluRsarewidelydistributedthroughoutthenervoussystemandareexpressedbybothneuronsandglialcells.mGluRshavebeensuggestedtoplayavarietyoffunctionalroles,amongwhichisinvolvementinsynapticplasticityunderlyinglearningandmemoryaswellaschronicpain.
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