Chemical Name: 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl piperidine-1-carboxylate
Purity: ≥98% (HPLC)
Biological Activity
Technical Data
Solubility
Calculators
Datasheets
References
Biological Activity
Selective Lysosomal acid lipase inhibitor (IC50 = 152 nM). Exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).
Technical Data
M. Wt
296.39
Formula
C13H20N4O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
CAS Number
1234569-09-5
PubChem ID
46867138
InChI Key
PNYYVHOTXOEBEV-UHFFFAOYSA-N
Smiles
O=C(N1CCCCC1)OC2=NSN=C2N3CCCCC3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent
Max Conc. mg/mL
Max Conc. mM
Solubility
DMSO
29.64
100
ethanol
29.64
100
Preparing Stock Solutions
The following data is based on the product molecular weight 296.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
1 mM
3.37 mL
16.87 mL
33.74 mL
5 mM
0.67 mL
3.37 mL
6.75 mL
10 mM
0.34 mL
1.69 mL
3.37 mL
50 mM
0.07 mL
0.34 mL
0.67 mL
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Product Datasheets
Certificate of Analysis / Product Datasheet
Safety Datasheet
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References
References are publications that support the products' biological activity.
Rosenbaumet al (2009) Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. Biochim.Biophys.Acta. 1791 1155 PMID: 19699313
Hamiltonet al (2012) A new method for the measurement of lysosomal acid lipase in dried blood spots using the inhibitor Lalistat 2. Clin.Chim.Acta. 413 1207 PMID: 22483793
Rosenbaumet al (2010) Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J.Med.Chem. 53 5281 PMID: 20557099