BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
SelectivehighaffinityEcto-5'-nucleotidase/CD73inhibitor(Kivaluesare2.21and9.03nMathumanandratCD73,respectively).Blocksecto-5'-nucleotidase-mediatedadenosineproductionbypreventingtheconversionofAMPtoadenosine.Exhibitsselectivityoverotherecto-nucleotidasesandADP-activatedP2Yreceptorstested.
TechnicalData
| M.Wt | 559.31 |
| Formula | C18H21N5Na2O9P2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| Smiles | O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(NCC4=CC=CC=C4)=C3N=C2)O[C@@H]1COP(CP(O)(O[Na])=O)(O[Na])=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleinwater(suppliedpre-dissolvedataconcentrationof10mM) |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight559.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 1.79mL | 8.94mL | 17.88mL |
| 5mM | 0.36mL | 1.79mL | 3.58mL |
| 10mM | 0.18mL | 0.89mL | 1.79mL |
| 50mM | 0.04mL | 0.18mL | 0.36mL |
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