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Tocris/Nutlin 3a/6075/5/5 mg
  • Tocris/Nutlin 3a/6075/5/5 mg

Tocris/Nutlin 3a/6075/5/5 mg

价格: ¥2340.00 市场价: 3900.00
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货号: 6075
品牌: Tocris
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    • Description:MDM2antagoNIST;activeenantiomerofNutlin-3(Cat.No.3984)
      ChemicalName:4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
      Purity:≥97%(HPLC)
      BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

      BiologicalActivity

      MDM2antagonist(IC50=90nM);inhibitstheMDM2-p53interaction.ActiveenantiomerofNutlin-3(Cat.No.3984).InducesexpressionforP53regulatedgenes.Suppressestumorgrowthinvivo>98%inprostatecancerandosteosarcomacancermodels.Antiproliferative.

      TechnicalData

      M.Wt581.49
      FormulaC30H30Cl2N4O4
      StorageStoreat-20°C
      Purity≥97%(HPLC)
      CASNumber675576-98-4
      PubChemID11433190
      InChIKeyBDUHCSBCVGXTJM-WUFINQPMSA-N
      SmilesClC1=CC=C([C@H]2[C@H](N(C(N3CC(NCC3)=O)=O)C(C4=CC=C(OC)C=C4OC(C)C)=N2)C5=CC=C(Cl)C=C5)C=C1

      Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

      AllTocrisproductsareintendedforlaboratoryresearchuseonly.

      SolubilityData

      SolventMaxConc.mg/mLMaxConc.mM
      Solubility
      DMSO58.15100
      ethanol58.15100

      PreparingStockSolutions

      Thefollowingdataisbasedontheproductmolecularweight581.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

      Concentration/SolventVolume/Mass1mg5mg10mg
      1mM1.72mL8.6mL17.2mL
      5mM0.34mL1.72mL3.44mL
      10mM0.17mL0.86mL1.72mL
      50mM0.03mL0.17mL0.34mL