当前位置 ： Tocris >>> Tocris/LDN 193189 dihydrochloride/6053/50/50 mg
Tocris/LDN 193189 dihydrochloride/6053/50/50 mg
  • Tocris/LDN 193189 dihydrochloride/6053/50/50 mg

Tocris/LDN 193189 dihydrochloride/6053/50/50 mg

价格: ¥9540.00 市场价: 15900.00
打印产品信息
货号: 6053/50
品牌: Tocris
规格
数量
库存(0)
特别 提示
代购产品：无质量问题不接受退换货，下单前请仔细核对信息。
下单后请及时联系客服核对商品价格，订单生效后再付款。
立即购买 加入购物车

收藏商品
资深产品顾问
咨询顾问

全国免费服务热线

4000-520-616

  • 自营商城 一站式服务
  • 厂家直采 剔除溢价
  • 品质甄选 正品保证
  • 严控流程 只做188精品
  • 极速物流 如约送货
  • 详情
  • 使用说明
  • 常见问题
    • Description:PotentandselectiveALK2andALK3inhibitor;promotesneuralinductionofhPSCs
      ChemicalName:4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinolinedihydrochloride
      Purity:≥98%(HPLC)
      BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

      BiologicalActivity

      PotentandselectiveALK2andALK3inhibitor(IC50valuesare5and30nM,respectively);inhibitsBMP4-mediatedSmad1/5/8activation.Exhibits>200-foldselectivityforBMPsignalingoverTGF-βsignaling.AlsoexhibitsselectivityoverAMPK,PDGFRandMAPKsignaling.PromotesneuralinductionofhPSCsincombinationwithSB431542(Cat.No.1614).AlsoinducesdifferentiationofhPSCsintonociceptivesensoryneuronsincombinationwithSB431542(Cat.No.1614),SU5402(Cat.No.3300),CHIR99021(Cat.No.4423)andDAPT(Cat.No.2634).

      LicensingInformation

      SoldforresearchpurposesunderexclusiveagreementfromTheBrighamandWomen'sHospitalInc.USpatents8,507,501and9,045,484

      iPSdifferentiationwithLDN193189

      iPS differentiation with LDN 193189

      ImageshowsIBJ6humanfibroblastinducedpluripotentstemcellswhichhavebeendifferentiatedintomotorneurons.ThiswasperformedusingacombinationofLDN193189(100nM)andSB431542(Cat.No.1614)followedbyRetinoicacid(Cat.No.0695)andPurmorphamine(Cat.No.4551)cultureonLamininfor18days.CommitmenttothemotorneuronfatewasaccessedusingthemotorneuronMarkeranti-HumanIslet-1(red,R&DSystems®,Cat.No.AF1837)andthegeneralneuronalmarker,betaIIItubulin(green,R&DSystems®,Cat.No.MAB1195).Forvisualization,theneuronswerestainedusingNorthernlights™557-conjugatedDonkeyanti-GoatSecondaryAntibody(R&DSystems®,Cat.No.NL001)andNorthernlights™493-conjugatedDonkeyanti-MouseSecondaryAntibody(R&DSystems®,Cat.No.NL009).

      TechnicalData

      M.Wt479.4
      FormulaC25H22N6.2HCl
      StorageStoreat-20°C
      Purity≥98%(HPLC)
      CASNumber1435934-00-1
      PubChemID91900717
      InChIKeyCMQXLLAILGGLRV-UHFFFAOYSA-N
      SmilesN1(C2=CC=C(C3=CN4N=CC(C5=CC=NC6=C5C=CC=C6)=C4N=C3)C=C2)CCNCC1.Cl.Cl

      Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

      AllTocrisproductsareintendedforlaboratoryresearchuseonly.

      SolubilityData

      SolventMaxConc.mg/mLMaxConc.mM
      Solubility
      DMSO9.5920
      water23.9750

      PreparingStockSolutions

      Thefollowingdataisbasedontheproductmolecularweight479.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

      Concentration/SolventVolume/Mass1mg5mg10mg
      1mM2.09mL10.43mL20.86mL
      5mM0.42mL2.09mL4.17mL
      10mM0.21mL1.04mL2.09mL
      50mM0.04mL0.21mL0.42mL

      ProductDatasheets

      CertificateofAnalysis/ProductDatasheet
      SafetyDatasheet

      客户服务

      在线客服
      用户反馈

      何为188

      极简而严谨，我们仅销售188款生物医学科研用品，款款都是爆款；因为少所以聚焦，聚焦甄选每一款产品，聚焦服务每一位客户!

      关注我们 :

      点击QQ联系我们
      生物188微信

      关注188微信公众号

      获取最新优惠活动通知

      • 品质甄选，正品保证

      • 自营电商，厂家直采

      • 极简主义，188精品

      常见问题 | 购买相关 | 配送与验收 | 支付问题 | 售后与服务 | 服务协议 | 隐私政策 | 何为188 | 中国智造 | 联系我们
      友情链接： DB Biotech产品 | 荧光封片剂Polysciences | PromoKine公司 | Altogen Biosystems代理 | Rierden产品代理 | biovision K249-50 | supertechsinc代理 | 蚂蚁淘 | 北京国谱科技有限公司

      公司版权所有 © 2005-2021 苏州蚂蚁淘生物科技有限公司 苏ICP备17049038号-10