BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
SelectiveRev-Erbα/βagonist(IC50valuesare160and170nMforRev-ErbβandRev-Erbαrespectively).Exhibitsnosignificantactivityagainstawiderangeofnuclearreceptors,otherreceptors,ionchannelsandtransportersat20μM.Increaseswakefulness,reducesREMandslowwavesleepinvivo.Alsoreducesanxiety-likebehaviorinmarble-buryingassay.Cellpermeableandbrainpenetrant.
TechnicalData
| M.Wt | 465.58 |
| Formula | C31H31NO3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1380548-02-6 |
| Smiles | CC(C)(OC1=CC=C(C=C1)OCC2CC3=CC=CC=C3CN2C(C4=CC=CC5=C4C=CC=C5)=O)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
|---|
| Solubility |
|---|
| DMSO | 2.33 | 5mMwithgentlewarming |
| ethanol | 2.33 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight465.58.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|
| 1mM | 2.15mL | 10.74mL | 21.48mL |
| 5mM | 0.43mL | 2.15mL | 4.3mL |
| 10mM | 0.21mL | 1.07mL | 2.15mL |
| 50mM | 0.04mL | 0.21mL | 0.43mL |
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